New York State Psychiatry Institute
  • 01-Nov-2018 to 01-Jan-2019 (EST)
  • PI- Molecular Therapeutics
  • New York, NY, USA
  • $54,390 + $3,026 location pay
  • Salary
  • Full Time

Full benefits package based on percentage of full-time effort


The Research Foundation for Mental Hygiene, Inc. is seeking a qualified post-doctoral candidate to conduct NIMH-funded research on dopamine neuron glutamate cotransmission.

This research will focus on the synaptic impact of reductions in the glutamate-synthetic enzyme glutaminase (gene Gls1) on dopamine neuron dopamine and glutamate release (Aim 1). INTRSECT will be used to identify dopamine neurons capable of glutamate cotransmission, and to enable selective optogenetic stimulation for behavioral analyses. Glutaminase inhibition pharmacotherapy will be tested (Aim 3) first in brain slices, to show that pharmacological inhibition of glutaminase and genetic reduction of Gls1 similarly and preferentially impact dopamine neuron glutamate cotransmission. Finally, both global and dopamine-neuron restricted Gls1 reductions will be made in adulthood to model pharmacotherapy. Techniques include, but are not limited to, slice electrophysiology, immunocytochemistry, viral-mediated neuroanatomy, inducible viral or transgenic systems, optogentics, in vivo imaging of single cell activity, mouse behavioral analyses, and gene expression analysis.

Successful candidates will hold (or be near completion of) a PhD in neuroscience or related field, and should be available to start on or about January 2019. Candidate must possess excellent oral and written communication skills, be highly self-motivated, collegial, and be able to work independently.

Strong preference will be given to candidates with patch clamp electrophysiology, optogenetics, and mouse behavioral analysis experience.

 

To apply:   Submit an application with cover letter and resume by January 1, 2019 through our website https://nyspi.applicantpro.com/jobs/. Only applications submitted through the RFMH website will be accepted.

 

The Research Foundation is a private not-for-profit corporation and is not an agency or instrumentality of the State of New York. Employees of the Research Foundation are not state employees, do not participate in any state retirement system, and do not receive state fringe benefits. Excellent Benefits Package. Employer/Minority/Women/Disabled/Veteran Employer. VEVRAA  41 CFR 60-300.5(a) compliant.

New York State Psychiatry Institute
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